東京家政大学研究者情報データベース

オオニシ　ジュンジ onishi junji
大西　淳之

所属東京家政大学栄養学部管理栄養学科
東京家政大学大学院人間生活学総合研究科健康栄養学専攻
東京家政大学大学院人間生活学総合研究科人間生活学専攻
東京家政大学短期大学部短期大学部栄養科
職種教授

論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Differential roles of rennin and angiotensinogen in the feto-maternal interface to the development of complications of pregnancy.
掲載誌名	正式名：Molecular Endocrinology 略　称：Mol.Endocrinol. ISSNコード：08888809
掲載区分	国外
巻・号・頁	19(5),pp.1361-1372
著者・共著者	◎Takimoto-Ohnishi E1, Saito T, Ishida J, Ohnishi J, Sugiyama F, Yagami K, Fukamizu A.
発行年月	2005/02
概要	We previously identified a transgenic mouse model that developed pregnancy-associated hypertension (PAH) and intrauterine growth restriction (IUGR) by mating females expressing human angiotensinogen (hANG) with males expressing human renin (hRN). These phenotypic defects were not observed in the opposite type of mating combination, despite the feto-placental overexpression of hRN and hANG detected in both types of crossbreeding. Detailed analysis of transgene localization in the labyrinth and its permeability to the maternal circulation revealed that hRN produced in trophoblast giant cells was secreted into the maternal circulation, whereas hANG, produced in chorionic trophoblasts and trophoblastic epithelium, was undetectable in the maternal plasma, probably due to their distinct spatial and temporal expression in labyrinth. These results demonstrated that PAH and IUGR could be mediated by feto-placental hRN through its permeability to the maternal circulation, not by feto-placental hANG production. Furthermore, overexpression of maternally derived hANG in decidua and spiral arteries of pregnant females with PAH and IUGR raises the possibility of local activation of the renin-angiotensin system and its pathophysiological effects on placental hypoperfusion in complications of pregnancy. This study provides in vivo evidence that the cell-specific expression of RN and ANG in the feto-maternal interface impacts their differential roles in pregnancy.
DOI	http://dx.doi.org/10.1210/me.2004-0158