オオニシ　ジュンジ  onishi junji
大西　淳之

  • 所属   東京家政大学  栄養学部 管理栄養学科
  •     東京家政大学大学院  人間生活学総合研究科 健康栄養学専攻
  •     東京家政大学大学院  人間生活学総合研究科 人間生活学専攻
  •     東京家政大学短期大学部  短期大学部 栄養科
  • 職種   教授
論文種別 原著
言語種別 英語
査読の有無 査読あり
表題 Tickling during adolescence alters fear-related and cognitive behaviors in rats after prolonged isolation.
掲載誌名 正式名：Physiology & Behavior
略　 称：Physiol Behav
ISSNコード：00319384
掲載区分国外
巻・号・頁 131,pp.62-67
著者・共著者 ◎Hori M, Yamada K, Ohnishi J, Sakamoto S, Furuie H, Murakami K, Ichitani Y
発行年月 2014/05
概要 Social interactions during adolescence are important especially for neuronal development and behavior. We recently showed that positive emotions induced by repeated tickling could modulate fear-related behaviors and sympatho-adrenal stress responses. In the present study, we examined whether tickling during early to late adolescence stage could reverse stress vulnerability induced by socially isolated rearing. Ninety-five male Fischer rats were reared under different conditions from postnatal day (PND) 21 to 53: group-housed (three rats/cage), isolated-nontickled (one rat/cage) and isolated-tickled (received tickling stimulation for 5 min a day). Auditory fear conditioning was then performed on the rats at PND 54. Isolated-tickled rats exhibited significantly lower freezing compared with group-housed rats in the first retention test performed 48 h after conditioning and compared with isolated-nontickled rats in the second retention test performed 96 h after conditioning. Moreover, group-housed and isolated-tickled rats tended to show a significant decrease in freezing responses in the second retention test; however, isolated-nontickled rats did not. In the Morris water maze task that was trained in adulthood (PND 88), but not in adolescence (PND 56), isolated-nontickled rats showed slower decrease of escape latency compared to group-housed rats; however, tickling treatment significantly improved this deficit. These results suggest that tickling stimulation can alleviate the detrimental effects of isolated rearing during adolescence on fear responses and spatial learning.
DOI doi:10.1016/j.physbeh.2014.04.008