オオニシ ジュンジ onishi junji
大西 淳之
- 所属 東京家政大学 栄養学部 管理栄養学科
- 東京家政大学大学院 人間生活学総合研究科 健康栄養学専攻
- 東京家政大学大学院 人間生活学総合研究科 人間生活学専攻
- 東京家政大学短期大学部 短期大学部 栄養科
- 職種 教授
| 論文種別 | 原著 |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | Alteraions of angiotensin II receptor contents in hypertrophied hearts. |
| 掲載誌名 | 正式名：Biochemical and Biophysical Research Communications 略 称：Biochem Biophys Res Commun ISSNコード：0006291X/10902104 |
| 掲載区分 | 国外 |
| 巻・号・頁 | 212(2),pp.326-333 |
| 著者・共著者 | ◎Fujii N, Tanaka M, Ohnishi J, Yukawa K, Takimoto E, Shimada S, Naruse M, Sugiyama F, Yagami K, Murakami K, |
| 発行年月 | 1995/07 |
| 概要 | Tsukuba hypertensive mice, which carry the human genes for renin and angiotensinogen, show cardiac hypertrophy as well as hypertension due to activation of the renin-angiotensin system (RAS). Here, we compared the cardiac angiotensin II (Ang II) receptor contents in these and normotensive control mice by means of ligand binding studies and competitive reverse transcription-polymerase chain reaction analyses. The content of the Ang II receptor type 1 (AT1) was significantly higher at both the protein (2.5-fold; p < 0.01) and mRNA (1.4-fold; p < 0.05) levels in the hypertensive mice than that in control mice. Almost identical levels of the Ang II receptor type 2 (AT2) expression were identified at the mRNA levels in the two types of mice, although the levels were less than 20% of those of AT1 mRNA in control mice. These results suggest that AT1 in the heart is upregulated in response to Ang II-induced hypertrophic change and that, in particular, the upregulation of AT1 in particular contributes to the development and/or maintenance of cardiac hypertrophy in conjunction with the increase in Ang II production, because AT1 is responsible for cardiac hypertrophy related to the RAS. |
| DOI | doi:10.1006/bbrc.1995.1973 |
| PMID | PMID: 7542873 |