オガタ　マキコ  ogata makiko
尾形　真規子

  • 所属   東京家政大学  栄養学部 管理栄養学科
  •     東京家政大学短期大学部  短期大学部 栄養科
  •     東京家政大学大学院  人間生活学総合研究科 健康栄養学専攻
  •     東京家政大学大学院  人間生活学総合研究科 人間生活学専攻
  • 職種   教授
論文種別 原著
言語種別 英語
査読の有無 査読あり
表題 Absence of the Gly40-ser mutation in the glucagon receptor gene in Japanese subjects with NIDDM.
掲載誌名 正式名：Diabetes research and clinical practice
略　 称：Diabetes Res Clin Pract
ISSNコード：01688227/01688227
掲載区分国外
巻・号・頁 33(2),pp.71-74
著者・共著者 Ogata M, Iwasaki N, Ohgawara H, Karibe S, Omori Y
発行年月 1996/07
概要 Recent studies have shown both association and linkage between a Gly40-Ser mutation in the glucagon receptor gene and NIDDM in French patients with familial NIDDM. This mutation was present in heterozygous form in 4.6% of diabetic probands but only 1% of the French population, suggesting that it was an important risk factor in the development of NIDDM. A total of 348 unrelated Japanese subjects (220 with NIDDM, 53 with impaired glucose tolerance (IGT) and 75 normal subjects) were screened for the presence of the Gly40-Ser mutation. Seventy-two percent of the NIDDM patients and 52% of IGT subjects had a positive family history of NIDDM. The Gly40-Ser mutation, which could be readily detected in a positive control subject, was not found in any of the 348 Japanese subjects studied. Thus, the Gly40-Ser mutation does not play an important role in the pathogenesis of NIDDM in Japanese patients.
PMID 8879960