シゲムラ ヤスタカ shigemura yasutaka
重村 泰毅
- 所属 東京家政大学短期大学部 短期大学部 栄養科
- 東京家政大学 家政学部 栄養学科
- 東京家政大学大学院 人間生活学総合研究科 健康栄養学専攻
- 東京家政大学大学院 人間生活学総合研究科 人間生活学専攻
- 職種 准教授
| 論文種別 | 原著 |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | Detection of Balenine in Mouse Plasma after Administration of Opah-Derived Balenine by HPLC with PITC Pre-Column Derivatization |
| 掲載誌名 | 正式名：Foods ISSNコード：2304-8158 |
| 掲載区分 | 国外 |
| 出版社 | MDPI |
| 巻・号・頁 | 11(4),pp.590 |
| 著者・共著者 | Yasutaka Shigemura, Yu Iwasaki, Yoshio Sato, Tomomi Kato, Takuya Seko, and Kenji Ishihara |
| 担当区分 | 筆頭著者,責任著者 |
| 発行年月 | 2022/02 |
| 概要 | We examined the absorption of balenine (Bal) in mouse blood after the administration of a high-purity Bal prepared from opah muscle. Using HPLC with phenyl isothiocyanate pre-column derivatization, we successfully isolated imidazole peptides and their constituents. We detected Bal and 3-methylhistidine (3-Me-His) in mouse blood 1 h after the administration of opah-derived Bal. The concentrations of Bal and 3-Me-His significantly increased to 128.27 and 69.09 nmol/mL in plasma, respectively, but were undetectable in control and carnosine (Car)-administrated mice. In contrast, β-alanine and histidine did not increase in mouse plasma 1 h after the administration of Car and opah-derived Bal. The present study is the first report on the absorption of food-derived Bal in mouse blood and serves as a pilot study for future clinical trials. |