シゲムラ ヤスタカ  shigemura yasutaka
重村 泰毅

  • 所属   東京家政大学短期大学部  短期大学部 栄養科
  •     東京家政大学  家政学部 栄養学科
  •     東京家政大学大学院  人間生活学総合研究科 健康栄養学専攻
  •     東京家政大学大学院  人間生活学総合研究科 人間生活学専攻
  • 職種   准教授
論文種別 原著
言語種別 英語
査読の有無 査読あり
表題 Detection of Balenine in Mouse Plasma after Administration of Opah-Derived Balenine by HPLC with PITC Pre-Column Derivatization
掲載誌名 正式名:Foods
ISSNコード:2304-8158
掲載区分国外
出版社 MDPI
巻・号・頁 11(4),pp.590
著者・共著者 Yasutaka Shigemura, Yu Iwasaki, Yoshio Sato, Tomomi Kato, Takuya Seko, and Kenji Ishihara
担当区分 筆頭著者,責任著者
発行年月 2022/02
概要 We examined the absorption of balenine (Bal) in mouse blood after the administration of a high-purity Bal prepared from opah muscle. Using HPLC with phenyl isothiocyanate pre-column derivatization, we successfully isolated imidazole peptides and their constituents. We detected Bal and 3-methylhistidine (3-Me-His) in mouse blood 1 h after the administration of opah-derived Bal. The concentrations of Bal and 3-Me-His significantly increased to 128.27 and 69.09 nmol/mL in plasma, respectively, but were undetectable in control and carnosine (Car)-administrated mice. In contrast, β-alanine and histidine did not increase in mouse plasma 1 h after the administration of Car and opah-derived Bal. The present study is the first report on the absorption of food-derived Bal in mouse blood and serves as a pilot study for future clinical trials.